Regulation of the apoptosis/autophagy switch by propionic acid in ventromedial hypothalamus of rats with type 2 diabetes mellitus.

Larysa Natrus,Yuliia Osadchuk,Olha Lisakovska,Toralf Roch,Nina Babel,Yuliia Klys,Dmytro Labudzynskyi,Yuri Chaikovsky

Heliyon（2022）

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摘要

T2DM was associated with apoptosis activation leading to impairments in VMH. PA in combination with metformin may be effective against diabetes-induced cell death by switching apoptosis to autophagy in VMH.

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关键词

Apoptosis,Autophagy,Metformin,Propionic acid,Type 2 diabetes,Ventromedial hypothalamus

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