Design and Synthesis of Some New Biologically Active Indeno[1,2- c ]pyrazolones

The reaction between different arylhydrazones and ninhydrin (= indene-1,2-3-trione) in acetonitrile at room temperature is described to produce novel bioactive 1-(3-chlorophenyl)indeno[1,2- c ]pyrazol-4(1 H )-one analouges. In evaluations of the ability to inhibit the growth of different human cell lines and some pathogenic bacterial strains in vitro , compounds 3c and 3f showed significant potency compared with the reference drugs. Both derivatives interacted well with the active site of the BRAF protein, according to molecular docking studies.