A Hybrid Modeling Framework for City-Scale Dynamics of Multi-strain Influenza Epidemics

In the current paper we present a hybrid modeling framework which allows to simulate co-circulation of influenza strains in urban settings. It comprises a detailed agent-based model coupled with SEIR-type compartmental model. While the former makes it possible to simulate the initial phase of an outbreak when the heterogeneity of the contact network is crucial, the latter approximates the disease dynamics after the occurrence of mass infection thus dramatically increasing the framework performance. The numerical experiments with the model are presented and their results are discussed.