Emerging nanomedicines strategies focused on tumor microenvironment against cancer recurrence and metastasis

•A comprehensive overview of the role of the tumor microenvironment in cancer metastasis and recurrence.•Recent progress of techniques for tumor microenvironment targeting and reshaping are reviewed.•Advanced therapeutic strategies of nanomedicines focused on tumor microenvironment for anti-tumor metastasis and recurrence.•Perspectives, challenges, and possible solutions of nanomedicines in the clinical translation are discussed.