Therapeutic Effect of a New Heterocyclic Compound on Neuropathic Pain Release and Predicted its Derivatives Based on Deep Learning Method

After getting the crystal structure of the new compound, its therapeutic effect and mechanism on neuropathic pain was evaluated and explored. The content of the inflammatory cytokines released into the cerebrospinal fluid was measured with ELISA assay. The real time RT-PCR was conducted and the activation of the NF-xb in the spinal ghat cell was determined. Three drug molecules that have been selected from the deep learning framework show similar interaction mechanism as the title compound, since the compound has been used as the feed to the deep learning framework, thus, these selected drug molecules share common structural features with respect to the title compound.