Reductive Cleavage of 4 ' H-Spiro[indole-3,5 '-isoxazoles] En Route to with Anticancer Activities

JOURNAL OF ORGANIC CHEMISTRY(2022)

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摘要
Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4 ' H-spiro[indole-3,5 '-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)acetamides with antiproliferative properties.
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