Cerebrospinal fluid as a liquid biopsy for molecular characterization of brain metastasis in patients with non-small cell lung cancer.

Georgios Tsakonas,Vasisht Tadigotla,Sudipto K Chakrabortty, Giuseppe Stragliotto, Dalin Chan,Rolf Lewensohn, Wei Yu,Johan K Skog,Per Hydbring,Simon Ekman

JOURNAL OF THORACIC ONCOLOGY（2023）

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摘要

Our approach of combining ctDNA and exosomal RNA analyses in CSF presents a potential surrogate for BM biopsy. The specific variants that were only observed in the CNS compartments could serve as targets for individually tailored therapies in NSCLC patients with BM.

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关键词

cerebrospinal fluid, brain metastases, exosome analysis

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