The 3D enhancer network of the developing T cell genome is shaped by SATB1
Nature Communications(2022)
Abstract
Here the authors analyze the 3D genome structure of murine thymocytes and show that SATB1, a predominantly T-cell specific protein, helps to establish a regulatory, finer-scale organizational layer built upon a pre-existing chromatin scaffold mediated by other architectural proteins, such as CTCF.
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