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Mutation-guided Vaccine Design: A Process for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

Kevin Wiehe,Kevin O. Saunders,Victoria Stalls,Derek W. Cain,Sravani Venkatayogi,Joshua S. Martin Beem,Madison Berry,Tyler Evangelous,Rory Henderson,Bhavna Hora,Shi-Mao Xia,Chuancang Jiang,Amanda Newman,Cindy Bowman,Xiaozhi Lu,Mary E. Bryan, Joena Bal,Aja Sanzone,Haiyan Chen,Amanda Eaton,Mark A. Tomai,Christopher B. Fox,Ying K. Tam,Christopher Barbosa,Mattia Bonsignori,Hiromi Muramatsu, S. Muniralam,David C. Montefiori,Wilton B. Williams,Norbert Pardi,Ming Tian,Drew Weissman,Frederick W. Alt,Priyamvada Acharya,Barton F. Haynes

Cell Host & Microbe（2024）

Cited 7|Views46
Key words
HIV vaccine,vaccine design,improbable mutations,broadly neutralizing antibodies,affinity maturation,B cell development,mRNA vaccine
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