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Evaluation of treosulfan cumulative exposure in paediatric patients through population pharmacokinetics and dosing simulations.

Sebastian P A Rosser,Samiuela Lee,Shruti Kohli,Steven J Keogh,Jason Chung,Tracey O'Brien,Christopher Fraser,Andrew J McLachlan,Peter J Shaw,Christa E Nath

British journal of clinical pharmacology（2023）

Cited 1|Views21
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Abstract
Treosulfan disposition was described through allometric body weight and maturational age descriptors. Model-informed dosing is recommended for patients under 2 years. Treosulfan PK parameters and AUC were not influenced by patient disease.
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Key words
NONMEM,chemotherapy,modelling and simulation,oncology,population analysis,treosulfan
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