Continuous Twin-Screw wet granulation process with In-Barrel drying and NIR setup for Real-Time Moisture Monitoring

•Single unit operation wet granulation and drying by utilizing in-barrel drying during twin screw wet granulation at pilot scale.•Reduce manufacturing footprint, time, and environmental exposures while also presenting a truly continuous drying process to pair with continuous twin-screw wet granulation.•Screw configuration, vacuum and position, degree of fill, and surface area under vents most impactful factors to achieve single unit operation in-barrel drying during twin screw wet granulation.•Real-time NIR monitoring of residual moisture to expedite development time and minimize material waste during twin screw wet granulation.