Green, zero-waste pathway to fabricate supported nanocatalysts and anti-kinetoplastid agents from sugarcane bagasse

The conversion processes of sugarcane into direct-consumption sugar and juice are generating a tremendous amount of waste, the so-called sugarcane bagasse (SCB). Biochar preparation is among the practical solutions aiming to manage and valorize SCB into high added-value functional material (FM).Herein, we propose a novel zero-waste pathway to fabricate two FMs from one biomass. The SCB was first macerated and ultrasonicated to obtain the natural extract that served as bio-reducing medium. Then, the H2O/ EtOH-extracted SCB was in-situ impregnated with a bimetallic solution of copper and silver nitrates. The process produced an intermediate composite (FM0), Ag/Cu-Ag+/Cu2+-loaded SCB which was carbonized to elaborate Ag/Cu-Biochar (FM1), free Ag/Cu nanoparticles (FM2) were obtained by microwaving the residual liquid waste.FM1 exhibited high catalytic activity for the total Fenton-like degradation of methylene blue. The experimental data followed the pseudo-first and the pseudo-second order rate laws with apparent degradation rate constants K1 45 10-3 min-1 and K2 0.115 g.mg- 1.min- 1, respectively. FM0, FM1 and FM2 were tested as new anti-kinetoplastid materials against two flagellated protozoans namely the Leishmania spp and the Trypanosoma cruzi. Notably, Ag/Cu (FM2) showed exceptional leishmanicidal and trypanocidal effects with IC50 values of 2.909 +/- 0.051, 3.580 +/- 0.016 and 3.020 +/- 0.372 ppm for L.donovani, L. amazonensis and Trypanosoma cruzi, respectively. In this way, we combine green chemistry and agrowaste valorization in a full zero-waste process, to address the 3rd (indicator 3.3.5) and 6th (indicator 6.3.1) United Nations sustainable development goals, '' Good Health and Well-Being '' and '' Clean Water and Sanitation ''.