Smooth Muscle Cell Relaxation Worsens Aortic Dilatation and Clinical Presentation in a BAPN/Angiotensin II-Induced Aortic Dissection Model in Rats.

Quentin Pellenc, Sandy El Bitar,Arthur Darmon,Sébastien Dupont,Jean-Baptiste Michel,Guillaume Jondeau

Journal of vascular research（2022）

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摘要

SMC relaxation with ISDN increases aortic dilatation, worsens aortic prognosis, and reproduces human histological findings in a low-dose BAPN/AngII-induced aortic dissection model in rats.

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关键词

Aortic dilation,Aortic dissection,Experimental model,Extracellular matrix,Smooth muscle cell,Vasodilators

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