Deep Molecular and In Silico Protein Analysis of p53 Alteration in Myelodysplastic Neoplasia and Acute Myeloid Leukemia.

Kristóf Madarász,János András Mótyán,Judit Bedekovics,Zsófia Miltényi,Anikó Ujfalusi,Gábor Méhes,Attila Mokánszki

Cells（2022）

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摘要

These molecular and in silico protein data further support that MDS with increased-blast (MDS-IB) is an intermediate group between AML-MR and MDS with low-blast (MDS-LB) patients, which frequently progresses to AML and is therefore considered a pre-leukemic condition.

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关键词

TP53 gene,acute myeloid leukemia (AML),in silico bioinformatic analysis,myelodysplastic neoplasias (MDS),next-generation sequencing (NGS),p53 protein

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