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Hyaluronan Regulates Neuronal and Immune Function in the Rat Small Intestine and Colonic Microbiota after Ischemic/Reperfusion Injury.

Annalisa Bosi,Davide Banfi,Michela Bistoletti, Lucia Martina Catizzone,Anna Maria Chiaravalli,Paola Moretto,Elisabetta Moro,Evgenia Karousou,Manuela Viola,Maria Cecilia Giron,Francesca Crema,Carlo Rossetti,Giorgio Binelli,Alberto Passi,Davide Vigetti,Cristina Giaroni,Andreina Baj

Cells（2022）

Cited 2|Views24
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Abstract
enhanced HA levels after intestinal IRI favors harmful bacteria overgrowth, increases neutrophil infiltration and promotes the upregulation of bacterial target receptors, TLR2 and TLR4, in the , inducing a pro-inflammatory state. TLR2 and TLR4 activation may, however, underlay a provisional benefit on excitatory and inhibitory neuronal pathways underlying peristalsis.
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Key words
TLRs,enteric nervous system,intestinal ischemia/reperfusion injury,intestinal neuromuscular function,microbiota
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