Alteration of hippocampal Egr3, GABA A receptors, Il-1β, Il6 and Ccl3 expression in audiogenic tremor mice after seizure

Epilepsy & Behavior(2022)

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Abstract
•Hippocampal proinflammatory cytokines and GABA A receptors were altered after a seizure.•Overexpression of Ccl3 mRNA was observed in the hippocampus of naive tremor mice.•Hippocampal Il-1β and Ccl3 expression were downregulated in stimulated tremor mice.•Low expression of Egr3, Gabra1, and Gabra4 mRNA were detected in naive tremor mice.•Egr3, Gabra1, and Gabra4 expression increased in the hippocampus of stimulated mice.
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Key words
Audiogenic seizure,GABA A receptor,Proinflammatory cytokines,Neuroinflammation,Tremor mice
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