Facile, High-Yield, and Freeze-and-Thaw-Assisted Approach to Fabricate Bamboo-Derived Hollow Lignocellulose Microcapsules for Controlled Drug Release
ACS SUSTAINABLE CHEMISTRY & ENGINEERING(2022)
摘要
Microcapsules have attracted considerable attention on account of their fundamental values in the storage and release of various cargoes. However, most microcapsules derived from synthetic polymers are nondegradable and have a risk of microplastic pollution. Therefore, the development of renewable alternatives has become an increasingly attractive area in recent from discarded parenchyma cells of moso bamboo, which are biodegradable, low-cost, and eco-friendly, were prepared by delignification and freezing-and-thawing (FAT) processes. The yield of monodispersed LMs on the delignified bamboo was up to 24.89%, which reserved native cell structures with cellulose nanofibers and hierarchical porous structures. Owing to their higher specific surface area and O/C value, LMs exhibited an excellent encapsulation efficiency of 92.2% by using doxorubicin hydrochloride (DOX) as a model drug. A pH-responsive release profile of DOX at the pH of 3.4 and 6.8 was achieved due to the protonation of drugs and carriers trigged in acidic conditions. Finally, after embedding LMs@DOX in alginate beads to prevent the initial burst release, a sustained release behavior for DOX was realized. Our work provides a more sustainable alternative to microencapsulation and enables a high-value-added utilization of bamboo wastes.
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关键词
Bamboo,parenchyma cells,delignification,microcapsules,drug release
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