Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1.

Mirte Scheper,Anand Iyer,Jasper J Anink,Lucia Mesarosova,James D Mills,Eleonora Aronica

Neuropathology and applied neurobiology（2023）

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摘要

We validated SIRT1 as a target of miR-543 in the brain and showed its function as a potential biomarker. Our results highlight the idea that dysregulation of miR-543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD.

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关键词

Parkinson's disease,SIRT1,differential expression,grey matter,microRNAs,white matter

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