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Dosage optimization of voriconazole in children with haematological malignancies based on population pharmacokinetics.

Yun Wu,Chunle Lv,Dongni Wu,Jianying Qi,Rongda Cai,Siru Zhou,Chengxin Li,Yinyi Wei,Taotao Liu

Journal of clinical pharmacy and therapeutics（2022）

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Abstract
We successfully built a voriconazole PPK model for children with hematologic malignancies. Dosing regimens were developed for different patients based on the final model, which could enhance the rational use of voriconazole in children with haematological malignancies.
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Key words
children,dosage regime,haematological malignancies,population pharmacokinetics,voriconazole
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