Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction

Iman Jalilian,Santoshi Muppala,Maryam Ali,Johnathon D Anderson,Brett Phinney,Michelle Salemi,Phillip A Wilmarth,Christopher J Murphy,Sara M Thomasy,VijayKrishna Raghunathan

Experimental Eye Research（2023）

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摘要

•Bovine corneal endothelial cells deposit a matrix while maintaining cellular morphology.•Matrix deposited after TGFβ treatment are softer akin to human FECD.•Cell derived matrices may model cell-matrix interactions for FECD biology.

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关键词

Extracellular matrix (ECM),Fuchs endothelial corneal dystrophy (FECD),Atomic force microscopy (AFM),Proteomics,Ascorbic acid,Transforming growth factor- β

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