Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models.

Amy T Ku,Adelaide I J Young,Ahmed Atef Ibrahim,Wen Bu,Weiyu Jiang,Meng Lin,Laterrica C Williams,Bryant Lee McCue,George Miles,Chandandeep Nagi,Fariba Behbod,Yi Li

Cancer prevention research (Philadelphia, Pa.)（2023）

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摘要

PI3K protein is abnormally high in breast precancerous lesions. This preclinical study demonstrates that the FDA-approved anti-PI3K inhibitor alpelisib can prevent breast cancer and thus warrant future clinical trials in high-risk women.

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breast cancer,short-term

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