Magnetic hydrothermal carbonaceous nanospheres bonded cell membranes as a stable and reusable platform for discovering natural bioactive components

Sha Liu,Pingyu Ye,Zhenqi Sang,Wan Gong,Peng Sun,Shan Tao,Qiaoyan Zhang, Lupin Qin,Qiming Zhao

Chemical Engineering Journal（2022）

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摘要

•A cytomembrane bionic hydrothermal nanocarbon is developed for natural drug screening.•This nanoplatform is formed by the HTC onto Fe3O4 and amidation with cytomembrane.•The CM-MHCNs have excellent recognition ability, activity stability and reusability.•Two novel potential anti-osteoporosis compounds are discovered via the platform.

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关键词

Magnetic hydrothermal carbonaceous nanomaterials,Cell membrane,Covalent biofunctionalization,Biomimetic recognition,Drug screening,Improved stability and reusability

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