Whole-genome sequencing of extrachromosomal circular DNA of cerebrospinal fluid of medulloblastoma.

Yi Zhu,Zhihui Liu,Yuduo Guo,Shenglun Li,Yanming Qu,Lin Dai,Yujia Chen,Weihai Ning,Hongwei Zhang,Lixin Ma

FRONTIERS IN ONCOLOGY（2022）

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摘要

This study provides preliminary evidence of the characteristics and formation mechanism of eccDNAs in MB and CSF. Importantly, eccDNA-associated hub genes in CSF could be used as diagnostic and prognostic biomarkers for MB.

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关键词

GEO,differentially expressed genes,extrachromosomal circular DNAs (eccDNAs),liquid biopsy,medulloblastoma (MB)

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