Embryo-fetal developmental toxicity and toxicokinetics of loxoprofen tromethamine intravenously administered to pregnant rats.

Peng Yue, Xinxin Zhao, Fan Lu,Qingfa Gao,Hongqun Qiao, Jing Liu

Birth defects research（2023）

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摘要

In conclusion, the no-observed-adverse-effect level (NOAEL) and lowest-observed-adverse-effect level (LOAEL) of loxoprofen tromethamine were considered to be 1 and 10 mg/kg/day, respectively.

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embryo-fetal developmental toxicity,loxoprofen tromethamine,nonsteroidal anti-inflammatory drug,reproduction toxicity

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