Cyclin D1 expression, cell proliferation, and clonal persistence characterize primary cutaneous CD4 + small or medium T-cell lymphoproliferative disorder.

Ilske Oschlies,Katharina Kock,Thomas Wüseke,Julia Richter,Karoline Koch,Ulrike Wehkamp,Wolfram Klapper

Histopathology（2023）

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摘要

PCSM-LPD is a clinically indolent, albeit neoplastic, disease driven by clonal expansion of PD1(+)-cells. We demonstrate Cyclin D1-expression associated with accelerated proliferation as a surprising new biological feature of the disease.

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关键词

Cyclin D1,clonality,clusters,follicular T-helper cells,microdissection

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