HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes.

Aleksandra Boikova,Megan J Bywater,Gregory A Quaife-Ryan,Jasmin Straube, Lucy Thompson,Camilla Ascanelli,Trevor D Littlewood,Gerard I Evan,James E Hudson,Catherine H Wilson

Frontiers in cardiovascular medicine（2022）

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摘要

Co-expression of Cyclin T1 and Myc may be a therapeutically tractable approach for cardiomyocyte neo-genesis post injury, while cell death induced by HRas and Myc expression likely limits this option as a regenerative therapeutic target.

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关键词

HRas gene,Myc (c-Myc),cardiomyocyte,cell-cycle,proliferation

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