Presence, enzymatic activity, and subcellular localization of paraoxonases 1, 2, and 3 in human lung tissues

A Cavallero, P Puccini,V Aprile,M Lucchi,P G Gervasi,V Longo,M Gabriele

Life Sciences（2022）

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摘要

•PON1, PON2, and PON3 activities estimation in several human lung tissues.•PONs subcellular distribution analysis in lung cytosol, microsomes, and mitochondria.•PONs activity was detected in lung cytosol, microsomes, and mitochondrial fractions.•High inter-individual variability in PONs expression and activities was found.•A549 cell line showed similar PONs activities to those observed in lung tissues.

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关键词

Paraoxonases,PONs expression,Organophosphate activity,Lactonase activity,Human lungs,A549 cell line

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