Hemin versus erythropoietin: Possible role in Nrf2/HO-1 signaling pathway in rats with nephrotoxicity.

Nahla E El-Ashmawy,Ghada M Al-Ashmawy, Amr A Farag,Amera O Ibrahim

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie（2022）

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摘要

The current results proved that hemin rather than EPO, showed reno-protective effects in rats, which was mediated by activation of Nrf2 signaling pathway. This could be also attributed to the observed anti-inflammatory, antioxidant, and anti-apoptotic properties of hemin. In this regard, EPO showed lower potency.

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关键词

Bcl2,Erythropoietin,Gentamicin,HO-1,Hemin,MDA,Nephrotoxicity,Nrf2,Oxidative stress

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