The impact of statistical properties of incremental monetary net benefit and incremental cost-effectiveness ratio on health economic modeling choices.
Expert review of pharmacoeconomics & outcomes research（2023）
Abstract
INMB's variance varies with a willingness-to-pay (WTP) threshold quadratically while ICER's variance with a WTP threshold value quadratically while ICER's variance with incremental-mean-cost quadratically. A simple and naïve model can sufficiently estimate ICER. Future metrics are expected to be health-economic-meaningful, unambiguous, unbiased, efficient, and statistical-inference-friendly.
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Key words
Restricted mean survival time (RMST),a two-state Markov micro-simulation model,incremental cost-effect ratio (ICER),incremental net monetary benefit (INMB),unbiasedness and efficiency
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