Effects of multidomain interventions on skeletal muscle architecture and function in pre-frail older women: The WiiProtein study

•Exergames alone or associated with protein supplementation improved musculoskeletal function.•Exergames alone or associated with protein supplementation reduced exhaustion/fatigue and reversed pre-frailty.•Exergames increased muscle architecture in pre-frail older women.•Protein supplementation improved exhaustion/fatigue in pre-frail older women.•Exergames and protein supplementation can be recommended to treat pre-frailty older women.