[Hydroxynitone suppresses hepatic stellate cell activation by inhibiting TGF-β1 phosphorylation to alleviate CCl 4 -induced liver fibrosis in rats].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University（2022）
Abstract
Hydronidone can inhibit the phosphorylation of the proteins in the TGF-β signaling pathway, thereby preventing TGF-β1-mediated activation of hepatic stellate cells, which may be a possible mechanism by which hydronidone alleviates CCl-induced liver fibrosis in rats.
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Key words
hepatic stellate cells,hydronidone,liver fibrosis,transforming growth factor β1
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