HIV Increases the Risk of Cigarette Smoke-Induced Emphysema via MMP-9.

Bashar S Staitieh,Simran Malik,Sara C Auld,Gregory W Wigger,Xian Fan,Andrew T Roth,Tanima Chatterjee,Itika Arora,S Vamsee Raju,Sonya Heath,Saurabh Aggrawal

Journal of acquired immune deficiency syndromes (1999)（2022）

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摘要

The combination of HIV and cigarette smoke increases MMP-9 expression in experimental rat HIV models and human subjects. HIV and cigarette smoke both induce alveolar oxidative stress and thereby increase MMP-9 activity.

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关键词

emphysema,HIV,smoking,metalloproteinase,Tat

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