TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres

Molecular Cell（2022）

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摘要

In this issue of Molecular Cell, Kaminski et al. and Yadav et al. demonstrate that RAD51AP1 and TERRA non-coding RNA positively regulate the alternative mechanism of telomere maintenance by promoting D-loop formation and chromatin-directed mechanisms to suppress transcription-collision events during ALT telomere synthesis.

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关键词

telomeres,alt,d-loop

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