Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches

Wanying Shi,Xu Gao,Yaqiang Cao,Yuanyuan Chen,Qian Cui,Fuchang Deng, Bo Yang,Elizabeth Z. Lin,Jianlong Fang,Tiantian Li,Song Tang,Krystal J. Godri Pollitt,Xiaoming Shi

Environment International（2022）

Cited 9|Views4

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Abstract

•Limited evidence depicting effects of airborne chemicals on ageing biomarkers.•PAEs, NIs, and PAHs significantly accelerated epigenetic age in the healthy elderly.•Exposure to chemicals mixture significantly accelerated the phenotypic age.•The adverse effect of airborne chemicals was mainly contributed by PAEs exposure.

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Key words

Airborne chemical mixture,Ageing biomarker,Weighted quantile sum (WQS) regression,Bayesian kernel machine regression (BKMR)

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