Bioavailability of dissolved and crushed single tablets of bictegravir, emtricitabine, tenofovir alafenamide in healthy adults: the SOLUBIC randomized crossover study.

Laurent Hocqueloux, Sandrine Lefeuvre, Julie Bois,Sylvie Brucato,Antoine Alix,Cécile Valentin,Laure Peyro-Saint-Paul, Laurence Got,François Fournel,Sylvie Dargere,Thierry Prazuck,Anna Fournier, Nicolas Gregoire,Ian McNicholl,Jean-Jacques Parienti

The Journal of antimicrobial chemotherapy（2022）

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摘要

Crushing BIC/TAF/FTC tablets may lead to suboptimal emtricitabine and tenofovir alafenamide drug exposures. Dissolving BIC/TAF/FTC in water may be acceptable if the tablet cannot be swallowed whole.

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tenofovir alafenamide,bictegravir,single tablets,emtricitabine

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