Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma.

Hope S Rugo,Kira Raskina,Alexa B Schrock,Russell W Madison,Ryon P Graf,Ethan S Sokol,Smruthy Sivakumar,Jessica K Lee,Virginia Fisher,Geoffrey R Oxnard,Hanna Tukachinsky

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

CGP detects diverse PIK3CAm in a greater number of patients with ABC than PCR hotspot testing; 20% of patients with PIK3CAm do not have SOLAR1m. These patients may derive benefit from alpelisib. See related commentary by Tau and Miller, p. 989.

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