B cell receptor profiling before and after IVIg monotherapy in newly diagnosed idiopathic inflammatory myopathies.

Dornatien C Anang,Hannah A W Walter,Johan Lim,Ilse Niewold,Linda van der Weele,Eleonora Aronica,Filip Eftimov,Joost Raaphorst,Barbera D C van Schaik,Antoine H C van Kampen,Anneke J van der Kooi,Niek de Vries

Rheumatology (Oxford, England)（2022）

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摘要

In treatment naïve patients with newly diagnosed IIM, muscle tissue and peripheral blood share expanded BcR clones. In our study a higher cumulative frequency of dominant BcR clones in blood before treatment was associated with a higher CK and better treatment response, suggesting that response to IVIg may depend on the composition of the pre-treatment BcR repertoire.

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关键词

B cell receptor sequencing,B cells,Idiopathic inflammatory myopathy,Intravenous immunoglobulin

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