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Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy

Jin Hu, Jianquan Shi, Yeshuang Yuan, Shengjie Li, Bo Zhang, Haitao Dong, Qing Zhong, Qiu Xie, Xiaoyin Bai, Yingxing Li

RSC ADVANCES（2022）

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Abstract
We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins.
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Key words
interferon,concatenation,antitumor efficacy,enhanced bioactivity,self-fused
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