Cyclic helix B peptide ameliorated the sepsis-induced injury in human HPMEC cells through regulating NF-κB.

WenJun Liu,DanLei Huang,YuJing Liu,HongYu He,ZhunYong Gu,YiMei Liu,QingNan Yang,Zhe Luo,MinJie Ju

Clinical immunology (Orlando, Fla.)（2022）

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摘要

CHBP ameliorated sepsis-induced injury dose dependently both in vitro and in vivo through decreasing the permeability of HPMEC cells via suppressing NF-κB signaling and inflammation. Present findings highlight the importance of CHBP/NF-κB signaling in septic injury and provide new insights into therapeutic strategies for sepsis-induced injury.

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关键词

Cell permeability,Cyclic helix B peptide,Inflammation,NF-κB activation,sepsis

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