RSV-induced expanded ciliated cells contribute to bronchial wall thickening

Sattya N Talukdar,Jaspreet Osan, Ken Ryan, Bryon Grove,Danielle Perley, Bony D Kumar, Shirley Yang, Sydney Dallman,Lauren Hollingsworth,Kristina L Bailey,Masfique Mehedi

Virus Research（2023）

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摘要

•RSV infects primarily ciliated cells in the bronchial airway epithelium.•RSV-induced expanded ciliated cells contribute to bronchial wall thickening.•RSV NS2, cytokines (INF-L1 and TNF-α) and chemokines (IP10/CXCL10), and ARP2/3-complex driven actin polymerization are more likely to involve RSV-induced infected ciliated cell expansion.

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关键词

RSV,Cytoskletal inflammation,ARP2/3-complex,NS2,Bronchiolitis,Bronchial wall thickening,Actin polymerization,IP10,Epithelial height,ALI,NHBE,ARP2

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