Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry

Washim Khan,Yan-Hong Wang,N.P. Dhammika Nanayakkara,H.M.T. Bandara Herath,Narayan D. Chaurasiya,Babu L. Tekwani,Mahmoud A. ElSohly,James D. McChesney,Ikhlas A. Khan,Larry A. Walker

Journal of Chromatography B（2022）

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摘要

•UPLC-MS/MS method for simultaneous quantification of primaquine and its metabolites in human urine.•Simple sample preparation with no apparent matrix effect.•The validated method was accurate, reliable, and complies with FDA guidelines.•Implementation of developed method on clinical pharmacokinetic analysis.•Primaquine orthoquinone, and glucuronide conjugation of PQ and carboxyprimaquine were the major metabolites in urine.

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关键词

Primaquine,UPLC-MS/MS,PQ metabolites,Urine analysis,Pharmacokinetic

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