RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.

Vagner Oliveira Carvalho Rigaud,Robert C Hoy,Justin Kurian,Clare Zarka,Michael Behanan,Isabella Brosious,Jennifer Pennise,Tej Patel,Tao Wang,Jaslyn Johnson,Lindsay M Kraus,Sadia Mohsin,Steven R Houser,Mohsin Khan

Circulation（2023）

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摘要

Collectively, LIN28a reprograms cardiomyocyte metabolism and promotes persistence of mononuclear diploid cardiomyocytes in the injured heart, enhancing proreparative processes, thereby linking cardiomyocyte metabolism to regulation of ploidy/nucleation and repair in the heart.

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关键词

RNA-binding proteins,metabolism,myocytes, cardiac,ploidies,regeneration

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