Bifunctional Sulfonamide as Hydrogen Bonding Catalyst in Catalytic Asymmetric Reactions: Concept and Application in the Past Decade

Since the first report of bifunctional sulfonamide organocatalysts in 2004, these chiral compounds have proven to be a reliable hydrogen-bonding catalyst and have been wildly employed in asymmetric organocatalysis due to its strong acidity and self-aggregation-free property. Herein, we review the application of bifunctional sulfonamide as hydrogen-bonding catalyst after 2011, and our highlights will cover asymmetric process including aldol reaction, Michael addition, Mannich reaction, desymmetrization and cyclization.