LINE-1 and Alu Methylation in hrHPV-Associated Precancerous Cervical Samples.

Arkom Chaiwongkot,Supranee Buranapraditkun,Suthipong Chujan,Nakarin Kitkumthorn

Asian Pacific journal of cancer prevention : APJCP（2022）

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摘要

We have demonstrated the LINE-1 and Alu methylation data in normal and premalignant cervical epithelia. LINE-1 hypomethylation was found in hrHPV positive normal cells, with lower methylation levels associated with cancer features. In cytologically diagnosed Atypical Squamous Cells of Unknown Significance (ASCUS), the levels of C and the CC pattern could be utilized in concert with hrHPV detection to classify the ASCUS sample prior to colposcopy.

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关键词

SIL,cervical cytology,global methylation,hrHPV

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