c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression.
Indian journal of pathology & microbiology(2022)
Abstract
Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab.
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Key words
HER2,c-MET,dual SISH/IHC,gastric carcinoma,immunohistochemistry,in situ hybridization
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