Four-Week Supplementation With Multi-Ingredient Nutrition Supplement Affects Biomarkers Of Metabolic Health In Metabolically Healthy Adults

Multicomponent nutritional formulas are rarely evaluated for their effectiveness and safety to protect metabolic health. We analyzed the effects of short-term supplementation with a multicomponent formula, AGELess DefenseTM, on blood pressure, clinical chemistry, and body composition in non-diabetic, non-hypertensive adults. Ten healthy mid-age adults (aged 47.5 ± 8.5 years; 7 women) volunteered to take part in this randomized, placebo-controlled cross-over pilot trial. The participants were allocated in a double-blind design to receive AGELess DefenseTM or placebo (inulin) during a 4-week intervention period. At the 4-week follow-up, AGELess DefenseTM reduced serum total and low-density lipoprotein cholesterol significantly more than the placebo (P = 0.05). Serum insulin levels increased significantly after consuming AGELess DefenseTM (P = 0.03), with AGELess DefenseTM having a medium-to-large effect size (d = 0.71). These preliminary findings suggest that AGELess DefenseTM is an effective nutritional intervention for protecting metabolic health; additional studies are warranted to corroborate this effect in metabolically compromised individuals.