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Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden.

Kwang Seob Lee,Jieun Seo,Choong-Kun Lee,Saeam Shin,Zisun Choi,Seungki Min, Jun Hyuek Yang,Woo Sun Kwon,Woobin Yun,Mi Ri Park,Jong Rak Choi,Hyun Cheol Chung, Seung-Tae Lee,Sun Young Rha

Clinical chemistry（2022）

Cited 6|Views12
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Abstract
The TMB500 assay is an accurate and reliable ctDNA assay for many clinical purposes. It may be useful for guiding the treatment of cancers with diverse genomic profiles, estimating TMB in immune therapy, and disease monitoring.
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Key words
circulating tumor DNA,liquid biopsy,next-generation sequencing,predictive biomarker,targeted gene panel,tumor mutational burden
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