Autoimmune regulator (AIRE): Takes a hypoxia-inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS.

Renjini Ambika Padmanabhan,Betcy Susan Johnson,Ajay Kumar Dhyani,Sathy M Pillai,K Jayakrishnan,Malini Laloraya

American journal of reproductive immunology (New York, N.Y. : 1989)（2023）

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摘要

Our consolidated results derive a new connection among AIRE-HIF1A-FOXP3 with AIRE reduction enabling increased HIF1A resulting in reduced FOXP3 in PBMCs of PCOS patients leading to Treg insufficiency.

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FOXP3,HIF1A,PCOS,autoimmune regulator (AIRE),tregs

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