Transcriptomic analyses of joint tissues during osteoarthritis development in a rat model reveal dysregulated mechanotransduction and extracellular matrix pathways.

Y Hu,K Li,H Swahn,P Ordoukhanian,S R Head, P Natarajan,A K Woods,S B Joseph, K A Johnson,M K Lotz

Osteoarthritis and cartilage（2022）

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摘要

These results indicate several shared pathways that are affected during OA in cartilage and meniscus and support the role of mechanotransduction and other pathways in OA pathogenesis.

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关键词

Mechanotransduction,Osteoarthritis,RNA sequencing

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