Adalimumab Therapy in Pediatric Crohn Disease: A 2-Year Follow-Up Comparing "Top-Down" and "Step-Up" Strategies.

Elise Payen,Antoine Neuraz,Letizia Zenzeri,Cécile Talbotec,Elie Abi Nader,Lucienne Chatenoud,Stephanie Chhun,Olivier Goulet,Frank M Ruemmele,Bénédicte Pigneur

Journal of pediatric gastroenterology and nutrition（2023）

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摘要

Early use of ADA appears to be more effective in maintaining relapse-free remission at 2 years, while using it as monotherapy. These findings further favor the recommendation of early anti-TNF use in high-risk CD patients.

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adalimumab,Crohn disease,pediatric,therapeutic strategy

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